AQUAMIN VEGETARIAN SEA MINERALS
AQUAMIN is the foundation of 4GRAMS. Everything else, the SuperFoods, Antioxidants, Vitamins, and Adaptogens are built on top of it - and AQUAMIN is a great co-factor for all these natural ingredients to work better. Like a good house, AQUAMIN provides a solid foundation.
People are becoming more conscious of the source and the form of the food and drink they consume. The future belongs to sustainable plant ingredients. The stone age has ended. We never use mined minerals or synthetic ones.
Aquamin® is a mineral blend derived from red algae harvested off the coasts of Ireland and Iceland. Aquamin® is an excellent vegetarian source of bioavailable Calcium and Magnesium with over 72 additional important trace minerals. Aquamin is a unique Marine multimineral complex, providing bioactive calcium, magnesium and 72 other trace marine minerals. Aquamin is derived from 100% seaweed, which absorbs trace minerals from the surrounding seawater. This form of absorption, coupled with Aquamins’s unique structure, results in a mineral rich product and easily absorbed by the human body.
- Preservation of bone structure and strength while on a high fat Western style diet
- Inhibition of Bone Mineral Density loss
- Aids the mineralisation and maturation of bone cells
- Fast & effective PTH suppression and protection from exercise-induced bone loss
- Aquamin & Vitamin D3 show proven synergy in enhancement of bone mineralisation
- Proven anti-inflammatory activity
- Pain and stiffness reduction for sufferers of osteoarthritis
- Ability for sufferers of osteoarthritis to reduce NSAID use by up to 50%
- Improvement of the symptoms of colitis
- Anti-inflammatory activity demonstrated in the GI tract
- Protection from liver damage while on a high fat Western diet
- Prevention of polyp formation on a high fat Western diet
- Maintenance of healthier stomach wall on a high fat Western diet
STUDY 1 Aquamin taken before exercise protects from exercise-induced bone loss.
Barry et al. (2011) “Acute Calcium Ingestion Attenuates Exercise Induced Disruption of Calcium Homeostasis”( Med Sci Sport Exerc 43(4):61723).
It is suggested that under certain conditions intense exercise can have detrimental effects on bone health, particularly for non-weight bearing exercise such as cycling. Excessive sweating during intense exercise may also result in excessive calcium loss through the skin, resulting in leaching of calcium from the bone and subsequent bone loss. Levels of PTH (parathyroid hormone) and CTX (both bone resorption markers) have previously been reported to increase during exercise (which would have a negative effect on bone).
20 male cyclists took placebo, Aquamin before or Aquamin during 3 different 35 km trials. PTH and CTX levels were investigated. No changes were seen in CTX levels probably due to an error in the time the blood was taken. However, significant differences were seen in PTH levels. Aquamin taken before exercise significantly reduced the increase in PTH as compared to placebo. There was a similar trend but no statistically significant differences between the Aquamin taken during exercise as compared to placebo.
STUDY 2 Aquamin positively contributes to Bone health as measured by DEXA. And bone turnover markers in post-Menopausal women.
Slevin et al., (2014) “Supplementation with calcium and short-chain fructo-oligosaccharides affects markers of bone turnover but not bone mineral density in postmenopausal women”( J Nutrition; In Press).
Osteoporosis is a global health problem with post-menopausal women at particularly high risk. It is known that dietary intake of calcium and other minerals is required to slow age-related bone loss.
The aim of this study is to investigate the effects of Aquamin either alone or in combination with a prebiotic fibre (the short-chain fructo-oligosaccharide, called Nutraflora) on the bone health of 300 post-menopausal women. Nutraflora was included as prebiotic fibres are known to increase calcium absorption from the gut.
This is a 2 year, randomized, double-blind, placebo-controlled study. The 300 women were divided into 3 groups, control (placebo), Aquamin only (800mg/day) or Aquamin + Nutraflora (3.6g/day). The treatments were given in the form of chocolate flavoured chews.
STUDY 3 Aquamin aids the mineralisation and maturation of bone cells.
O’Gorman et al. (2012) “ The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro”( Phytotherapy Res 26 (3) : 375-80).
Osteoporosis is a global health problem characterized by low bone density and increased bone fragility. A good diet is known to play an important role in bone health determining final bone mineral density and the extent of bone loss in later life. Diets lacking adequate minerals especially calcium, have been identified as risk factors for osteoporosis. In addition to calcium, several other minerals are also known to play a major role in bone health including magnesium, manganese, copper, zinc and selenium. It is also well known that many people do not reach the recommended daily intake (RDI) of minerals in their diet.
Osteoblasts are bone cells that play an essential role in bone metabolism and new bone formation. We examined the effects of Aquamin on an osteoblast cell line grown in-vitro. After 28 days in tissue culture we found that Aquamin greatly enhanced mineralization of the osteoblast cells increasing calcium, magnesium, manganese, barium, strontium and iron deposition in these cells. Aquamin had no negative effects on cell growth or metabolism under these conditions. This study suggests that Aquamin may play an important role in promoting bone formation.
STUDY 4 Parameters investigated Aquamin reduces the symptoms of osteoarthritis.
Frestedt et al. (2008) “A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial” (Nutrition Journal 7 : 9).
Osteoarthritis (OA) affects millions of people worldwide. However, despite extensive research the exact biochemical cause of OA remains unknown. Current medical treatments for OA (such as non-steroidal anti-inflammatory drugs: NSAIDS) while providing some relief from symptoms are suboptimal and have many side-effects. This study investigated the potential for Aquamin to alleviate OA symptoms.
70 male and female subjects with moderate to severe OA were recruited for this 12 week, randomised, double-blind, placebo-controlled, parallel group study. They were divided into 4 groups and given either placebo, Aquamin, Glucosamine sulphate or a combination of Aquamin and glucosamine sulphate over the 12 weeks.
At the start, during and at the end of the study the subjects were tested for pain, stiffness and activity by WOMAC questionnaire. The WOMAC questionnaire is a scientifically validated questionnaire to assess OA symptoms. They were also tested to see how far they could walk over a 6 minute period.
Results: Aquamin showed statistically significant improvements in all parameters measured. Aquamin also outperformed glucosamine in all the parameters measured. As expected the group taking the placebo showed no significant improvement in the parameters measured. Unexpectedly the group taking the combination of Aquamin and glucosamine sulphate also showed no improvement in their symptoms. This may be due to the mechanism of action of these two products. Aquamin has a basic pH while glucosamine is activated in an acidic environment. The ingestion of these two supplements simultaneously serves to cancel each of their effects.
Aquamin may be an important supplement in relieving the symptoms of OA.
STUDY 5 Pain, Range of Motion. Mobility – Walking Distance NSAID usage can be reduced by Aquamin intake.
Frestedt et al. (2009) “A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: a randomised, placebo-controlled pilot study” (Nutrition Journal 8:7).
Aquamin has been shown to exert beneficial effects on the symptoms of osteoarthritis (OA) decreasing pain and stiffness and increasing mobility and walking distance. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to relieve the pain and discomfort of osteoarthritis but often have unwelcome side effects (gastrointestinal problems, ulcers, cardiac risk). This study demonstrates that it is possible to reduce NSAID usage when taking Aquamin.
29 subjects (male and female) with moderate to severe OA were enrolled into this 12 week, randomised, double-blind, parallel group study. The subjects were divided into 2 groups and took either Aquamin or placebo over the 12 weeks. WOMAC scores for pain, stiffness and activity as well as the distance walked over 6 minutes (6MWD) and range of motion scores were measured. After 2 weeks on the treatments NSAIDs were reduced by 50% and it was found that subjects taking Aquamin showed significantly better 6MWD and range of motion than the placebo group. However, these differences were not seen when NSAID use was stopped completely.
This study shows that it is possible to reduce NSAID usage and still show an increase in walking distance and range of motion when taking Aquamin. This would have significant benefits for the many long-term users of NSAIDs. Also worth noting is the difficulty experienced in recruiting for this study. Many people expressed a significant fear at being asked to eliminate usage of NSAIDs. This underlines the pain experienced by sufferers of OA.
STUDY 6 Aquamin positively regulates the pro-inflammatory
activity of TNFα and IL-1β.
Ryan et al. (2011) “Evidence that the marine-derived multi mineral, Aquamin, has anti-inflammatory effects on cortical glial-enriched cultures” (Phytotherapy Res 25(5): 765-7).
We have previously shown that Aquamin has beneficial effects on the symptoms of osteoarthritis (OA) decreasing pain and stiffness, increasing mobility and walking distance and allowing for a reduction in NSAID usage. This suggested that Aquamin was working as an anti-inflammatory agent. This in-vitro study explains one of the mechanisms by which Aquamin exerts these anti-inflammatory effects.
Cytokines are a family of molecules that regulate the immune response and inflammation. Secretion of two of these molecules TNFα (tumour necrosis alpha) and IL-1β (interleukin-1beta) can lead to an inappropriate inflammatory response such as is seen with OA.
We used a rat cortical glial (brain) cell culture model to investigate the activity of TNFα and IL-1β in response to Aquamin treatment as this system is particularly sensitive to inflammation. We used a bacterial toxin, lipopolysaccharide (LPS) to stimulate inflammation and induce secretion of TNFα and IL-1β. Aquamin significantly inhibited both TNFα and IL-1β secretion in this system and may explain how Aquamin exerts its anti-inflammatory effects in OA.
STUDY 7 Aquamin positively regulatesthe pro-inflammatory activity of NFĸB.
O’ Gorman et al. (2012) “Evidence that marine-derived, multi-mineral, Aquamin, inhibits the NFκB signalling pathway in-vitro”( Phytotherapy Res 26(3):630-32).
We have previously shown that Aquamin has beneficial effects on the symptoms of osteoarthritis (OA) decreasing pain and stiffness, increasing mobility and walking distance and allowing for a reduction in NSAID usage. This suggested that Aquamin was working as an anti-inflammatory agent. This in-vitro study (in addition to the Ryan et al., 2010 study) describes a second mechanism by which Aquamin exerts its anti-inflammatory effects.
NFκB (nuclear factor kappa B) is considered the master regulator of the immune response controlling expression of many pro-inflammatory molecules including cyclo-oxygenase-2 (COX2). COX2 is the well established target for non-steroidal anti-inflammatory drugs (NSAIDs) used widely to provide relief from inflammation and pain.
We used immune (white blood) cells as the in-vitro system to investigate the effects of Aquamin on both NFκB and COX2 activity. We used a bacterial toxin, lipopolysaccharide (LPS) to stimulate inflammation and activate NFκB and COX2. Aquamin significantly inhibited both NFκB and COX2 activity in this system and this may explain the effectiveness of Aquamin in relieving the symptoms of OA.
STUDY 8 Aquamin positively regulates the pro-inflammatory activity of NFĸB.
STUDY 9 Aquamin positively regulates the pro-inflammatory activity of NFĸB.